MMV666810
Product Specifications
CAS Number
1450666-97-3
Target
Others|||Parasite
Related Pathways
Others|||Microbiology/Virology
Bioactivity
MMV666810, a 2-aminopyrazine analogue of MMV390048, exhibits potent antiplasmodial activity against asexual parasites with an IC50 value of 5.94 nM. It demonstrates enhanced efficacy against late-stage gametocytes with a 3.3-fold higher selectivity relative to early stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM) .
Smiles
NC=1C(=NC(=CN1)C2=CC=C(C(=O)N3CCC(O)CC3)C=C2)C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C23H21F3N4O2
Molecular Weight
442.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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