IC 86621
Product Specifications
CAS Number
404009-40-1
Target
DNA-PK, Apoptosis
Related Pathways
Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Purity
0.9968
Bioactivity
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break (DSB) -induced antitumor activity with an EC50 of 68 μM for DNA-PK mediated cellular DSB repair.
Smiles
CC(=O)c1ccc(cc1O)N1CCOCC1
Molecular Formula
C12H15NO3
Molecular Weight
221.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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