BLU-945
Product Specifications
CAS Number
2660250-10-0
Target
EGFR
Related Pathways
JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.9916
Bioactivity
BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs) . BLU-945 inhibits EGFR phosphorylation in EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S mutant cell lines. BLU-945 can be used in lung cancer research, including non-small cell lung cancer (NSCLC) .
Smiles
CO[C@@H]1CCN(C[C@@H]1F)c1nccc(Nc2cc3c(ccc(N4C[C@H](CS(C)(=O)=O)[C@H]4C)c3cn2)C(C)C)n1
Molecular Formula
C28H37FN6O3S
Molecular Weight
556.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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