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2'-Fluoro-2'-Deoxyadenosine

Product Specifications

CAS Number

64183-27-3

Target

Nucleoside Antimetabolite/Analog

Related Pathways

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Purity

0.9995

Bioactivity

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP) . 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

Smiles

Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F

Molecular Formula

C10H12FN5O3

Molecular Weight

269.23

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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