2'-Fluoro-2'-Deoxyadenosine
Product Specifications
CAS Number
64183-27-3
Target
Nucleoside Antimetabolite/Analog
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Purity
0.9995
Bioactivity
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP) . 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.
Smiles
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F
Molecular Formula
C10H12FN5O3
Molecular Weight
269.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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