DB2313
Product Specifications
CAS Number
2170606-74-1
Target
Apoptosis
Related Pathways
Apoptosis
Purity
0.9973
Bioactivity
DB2313 (Carboximidamide) is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects
Smiles
CC(C)NC(=N)c1ccc2nc([nH]c2c1)-c1ccc(OCc2cccc(COc3ccc(cc3)-c3nc4ccc(cc4[nH]3)C(=N)NC(C)C)c2F)cc1
Molecular Formula
C42H41FN8O2
Molecular Weight
708.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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