GSK778
Product Specifications
CAS Number
2451862-42-1
Target
Epigenetic Reader Domain|||Apoptosis
Related Pathways
Apoptosis|||Chromatin/Epigenetic
Purity
0.9842
Bioactivity
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM) . GSK778 inhibits proliferation, induces a cell cycle arrest and apoptosis.
Smiles
COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1
Molecular Formula
C30H33N5O3
Molecular Weight
511.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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