KRAS G12D inhibitor 1
Product Specifications
CAS Number
2621928-43-4
Target
Others, Kras, Ras
Related Pathways
Others, MAPK, GPCR/G Protein
Bioactivity
KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D, exhibiting an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1].
Smiles
Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2C[C@@H]3CC[C@H](C2)N3)c2c(cccc2c1)C#C
Molecular Formula
C33H32F2N6O2
Molecular Weight
582.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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