KRAS G12D inhibitor 1

2621928-43-4

Others|||Kras|||Ras

Others|||MAPK|||GPCR/G Protein

KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D, exhibiting an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1].

Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2C[C@@H]3CC[C@H](C2)N3)c2c(cccc2c1)C#C

C33H32F2N6O2

582.64

Cool pack

-20°C

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