AP-1/NF-κB activation inhibitor 1
Product Specifications
CAS Number
188936-12-1
Target
NF-κB, DNA/RNA Synthesis
Related Pathways
NF-κB, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
>99.99%
Bioactivity
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation (IC50 = 1 μM), without blocking basal transcription driven by the β-actin promoter. It has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells [1].
Smiles
CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)C(F)(F)F
Molecular Formula
C13H11F3N4O4
Molecular Weight
344.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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