NBC 6
Product Specifications
CAS Number
2068818-02-8
Target
NOD-like Receptor (NLR), Others
Related Pathways
Immunology/Inflammation, Others
Bioactivity
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with an IC50 of 574 nM. It acts independently of Ca 2+ and inhibits Nigericin-induced inflammasome activation in THP-1 cells, as well as Imiquimod-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) [1].
Smiles
C(Cl)(Cl)(Cl)C1=[NH][B+3](O=C(N)[C-]1C(C)=O)([C-]=2C=CC=CC2)[C-]=3C=CC=CC3
Molecular Formula
C18H16BCl3N2O2
Molecular Weight
409.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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