Triciferol
Product Specifications
CAS Number
957214-00-5
Target
Others|||Vitamin|||HDAC
Related Pathways
DNA Damage/DNA Repair|||Metabolism|||Chromatin/Epigenetic|||Others
Bioactivity
Triciferol acts as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC 50 =87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Triciferol also exhibits efficacious antiproliferative and cytotoxic activities in cancer cell models in vitro [1].
Smiles
[H][C@@]12CC[C@H]([C@H](C)\C=C(/C)\C=C\C(=O)NO)[C@@]1(C)CCC\C2=C/C=C1C[C@@H](O)C[C@H](O)C1
Molecular Formula
C26H39NO4
Molecular Weight
429.591
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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