IRE1? kinase-IN-1
Product Specifications
CAS Number
2328097-41-0
Target
IRE1
Related Pathways
Cell Cycle/Checkpoint
Purity
0.997
Bioactivity
IRE1? kinase-IN-1 is a highly selective IRE1? (ERN1) inhibitor, with an IC50 of 77 nM, displaying 100-fold selectivity over the IRE1? isoform. It inhibits ER stress-induced IRE1? oligomerization and autophosphorylation, as well as IRE1? RNase activity (IC50=80 nM) .
Smiles
CN1CCC(CNc2cc(Cl)nn3c(cnc23)-c2cc3nc(Nc4ccccc4)[nH]c3cc2F)CC1
Molecular Formula
C26H26ClFN8
Molecular Weight
504.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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