TNIK-IN-3
Product Specifications
CAS Number
2754265-25-1
Target
DAPK|||Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling|||Stem Cells|||Apoptosis
Purity
0.9956
Bioactivity
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK) . It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 ?M. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 ?M), Flt1 (IC50 = 0.191 ?M), and DRAK1 (IC50 = 0.411 ?M) . This compound holds potential for carrying out research on colorectal cancer (CRC) [1].
Smiles
Fc1ccc(CN2CCOc3cc(ccc3C2=O)-c2cnc3[nH]ccc3c2)cc1
Molecular Formula
C23H18FN3O2
Molecular Weight
387.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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