TNIK-IN-3

TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK) . It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 ?M. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 ?M), Flt1 (IC50 = 0.191 ?M), and DRAK1 (IC50 = 0.411 ?M) . This compound holds potential for carrying out research on colorectal cancer (CRC) [1].