BC-LI-0186
Product Specifications
CAS Number
695207-56-8
Target
Others
Related Pathways
Others
Purity
0.9971
Bioactivity
BC-LI-0186 (4- (2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl) -N- (2-phenoxyethyl) benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung cancer-related research.
Smiles
CC(C)c1c(C)n(C)n(-c2ccc(cc2)S(=O)(=O)NCCOc2ccccc2)c1=O
Molecular Formula
C22H27N3O4S
Molecular Weight
429.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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