Niraparib tosylate monohyrate
Product Specifications
CAS Number
1613220-15-7
Target
Apoptosis|||PARP
Related Pathways
Apoptosis|||DNA Damage/DNA Repair|||Chromatin/Epigenetic
Purity
0.9999
Bioactivity
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
Smiles
CC1=CC=C(S(=O)(O)=O)C=C1.O=C(N)C(C2=N3)=CC=CC2=CN3C(C=C4)=CC=C4[C@@H]5CCCNC5.O
Molecular Formula
C26H30N4O5S
Molecular Weight
510.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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