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ONO-8711 (dicyclohexylamine)

Selected Variant

HY-12182A-01

Size: 1 mg

ONO-8711 dicyclohexylamine is a selective and orally active EP1 competitive antagonist with Ki value of 0.6 nM and 1.7 nM for human and mouse EP1 respectively. ONO-8711 dicyclohexylamine effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer[1].

Product Specifications

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ono-8711-dicyclohexylamine.html

Purity

99.30

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CCC/C=C\[C@H]1C(CC2)CCC2[C@@H]1CNS(=O)(C3=CC=C(Cl)C=C3C)=O.C4(NC5CCCCC5)CCCCC4

Molecular Formula

C34H53ClN2O4S

Molecular Weight

621.31

References & Citations

[1]Watanabe K, et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res. 1999 Oct 15;59 (20) :5093-6.|[2]Norel X, et al. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74 (1-4) :101-12.|[3]Kawamori T, et al. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP (1) antagonist, on breast cancer development. Carcinogenesis. 2001 Dec;22 (12) :2001-4.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Price

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