HM43239
Product Specifications
CAS Number
2294874-49-8
Target
Apoptosis, FLT
Related Pathways
Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors
Purity
0.997
Bioactivity
HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells [1] [2] [3].
Smiles
C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Molecular Formula
C29H33ClN6
Molecular Weight
501.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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