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MRTX1133

Product Specifications

CAS Number

2621928-55-8

Target

Ras, Kras

Related Pathways

MAPK, GPCR/G Protein

Purity

0.996

Bioactivity

MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.

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Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2C[C@@H]3CC[C@H](C2)N3)c2c(C#C)c(F)ccc2c1

Molecular Formula

C33H31F3N6O2

Molecular Weight

600.63

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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