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MPP+ iodide

Product Specifications

CAS Number

36913-39-0

Target

Autophagy, Mitochondrial Metabolism

Related Pathways

Autophagy, Metabolism

Purity

0.9996

Bioactivity

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

Smiles

[I-].C=1C=CC(=CC1)C=2C=C[N+](=CC2)C

Molecular Formula

C12H12IN

Molecular Weight

297.13

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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