MPP+ iodide
Product Specifications
CAS Number
36913-39-0
Target
Autophagy, Mitochondrial Metabolism
Related Pathways
Autophagy, Metabolism
Purity
0.9996
Bioactivity
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
Smiles
[I-].C=1C=CC(=CC1)C=2C=C[N+](=CC2)C
Molecular Formula
C12H12IN
Molecular Weight
297.13
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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