UNC5293
Product Specifications
CAS Number
2226789-82-6
Target
Others, FLT, ALK, TAM Receptor
Related Pathways
Others, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
UNC5293 is a potent, orally available and highly MERTK-selective inhibitor with Ki of 190 pM. UNC5293 inhibits MERTK (IC 50 =0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research [1].
Smiles
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Molecular Formula
C30H42N6O2
Molecular Weight
518.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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