BI-0115
Product Specifications
CAS Number
4929-23-1
Target
Lipoxygenase
Related Pathways
Metabolism
Purity
0.9969
Bioactivity
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
Smiles
CCCN1c2cccnc2Nc2cc(Cl)ccc2C1=O
Molecular Formula
C15H14ClN3O
Molecular Weight
287.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
abx500385 96 Tests
Mouse Alpha/beta hydrolase domain-containing protein 17B (ABHD17B) ELISA Kit
Ask
View Details 