Topovale
Product Specifications
CAS Number
500214-53-9
Target
Topoisomerase
Related Pathways
DNA Damage/DNA Repair
Purity
0.9994
Bioactivity
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1) -deficient P388/CPT45 cells as compared with P388 cells.
Smiles
C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5
Molecular Formula
C23H23N3O5
Molecular Weight
421.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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