AES-350
Product Specifications
CAS Number
847249-57-4
Target
Apoptosis, HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis
Purity
0.992
Bioactivity
AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 μM and 0.035 μM, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 μM, 0.245 μM, and >1 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
Smiles
CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO
Molecular Formula
C18H20N2O3
Molecular Weight
312.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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