KY19382
Product Specifications
CAS Number
2226664-93-1
Target
GSK-3, Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Stem Cells, PI3K/Akt/mTOR signaling
Purity
0.9806
Bioactivity
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3- (methoxyimino) -2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β (IC50s of 19 and 10 nM, respectively) . It activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.
Smiles
CO\N=C1/C(/Nc2ccccc/12)=C1/C(=O)Nc2cc(Cl)c(Cl)cc12
Molecular Formula
C17H11Cl2N3O2
Molecular Weight
360.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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