SKI-178
Product Specifications
CAS Number
1259484-97-3
Target
S1P Receptor, Apoptosis
Related Pathways
Apoptosis, GPCR/G Protein
Purity
0.992
Bioactivity
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Smiles
COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
Molecular Formula
C21H22N4O4
Molecular Weight
394.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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