API-1
Product Specifications
CAS Number
36707-00-3
Target
Apoptosis, PARP, Caspase, Akt
Related Pathways
Cytoskeletal Signaling, Proteases/Proteasome, Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Purity
0.9907
Bioactivity
API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
Smiles
NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c2c1=O
Molecular Formula
C13H15N5O6
Molecular Weight
337.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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