HSMG-1 inhibitor 11j
Product Specifications
CAS Number
1402452-15-6
Target
PI3K|||mTOR|||GSK-3|||CDK
Related Pathways
PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint|||Stem Cells
Purity
0.9965
Bioactivity
HSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3K?/? (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 ?M) . hSMG-1 inhibitor 11j can be used for the research of cancer.
Smiles
CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)-c2ccnc(c2)-c2ccc(NC(=O)NC)cc2)ccc1Cl
Molecular Formula
C27H28ClN7O3S
Molecular Weight
566.07
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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