HSMG-1 inhibitor 11j
Product Specifications
CAS Number
1402452-15-6
Target
PI3K, mTOR, GSK-3, CDK
Related Pathways
PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Stem Cells
Purity
0.9965
Bioactivity
HSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM) . hSMG-1 inhibitor 11j can be used for the research of cancer.
Smiles
CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)-c2ccnc(c2)-c2ccc(NC(=O)NC)cc2)ccc1Cl
Molecular Formula
C27H28ClN7O3S
Molecular Weight
566.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC880034-500 1x 500 µL
Cytokeratin 8/18 (C-51), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042939-100 1x 100 µL
Spectrin Alpha 1 (Erythrocyte Marker) (SPTA1/2939R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402101-500 1x 500 µL
ATG5 (Autophagy Marker) (ATG5/2101), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742981-100 1x 100 µL
Tenascin C (Stromal Marker For Epithelial Malignancy) (TNC/2981R), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details