Bractoppin
Product Specifications
CAS Number
2290527-07-8
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.9965
Bioactivity
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t) BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
Smiles
Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1
Molecular Formula
C25H23FN4O
Molecular Weight
414.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2107049-01 0.1 mL
APC/Cy7 Linked Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)
Sign In for Pricing
View Details 
MBS2107049-02 0.2 mL
APC/Cy7 Linked Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)
Sign In for Pricing
View Details MBS2107049-03 0.5 mL
APC/Cy7 Linked Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)
Sign In for Pricing
View Details MBS2107049-04 1 mL
APC/Cy7 Linked Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)
Sign In for Pricing
View Details MBS2107049-05 5 mL
APC/Cy7 Linked Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)
Sign In for Pricing
View Details