Bractoppin
Product Specifications
CAS Number
2290527-07-8
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Purity
0.9965
Bioactivity
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t) BRCT domain (IC50 = 0.074 ?M), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
Smiles
Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1
Molecular Formula
C25H23FN4O
Molecular Weight
414.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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