GW779439X
Product Specifications
CAS Number
551919-98-3
Target
Apoptosis, Aurora Kinase, Antibacterial, CDK
Related Pathways
Apoptosis, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Microbiology/Virology
Purity
0.9923
Bioactivity
GW779439X is a pyrazolopyridazine compound that inhibits the S. aureus kinase Stk1 and Aurora kinase A (AURKA) . It restores the efficacy of β-lactam antibiotics against methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) S. aureus, often re-sensitizing resistant strains. This antibacterial potentiation is achieved through the induction of apoptosis via caspase-3/7 pathway activation.
Smiles
CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F
Molecular Formula
C22H21F3N8
Molecular Weight
454.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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