CAN508
Product Specifications
CAS Number
140651-18-9
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
CAN508 is a potent ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It also competitively inhibits Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 μM and 20 μM, respectively. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. [Antitumor activity.]
Smiles
Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1
Molecular Formula
C9H10N6O
Molecular Weight
218.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6392703-01 0.1 mL
RNF138 (NARF, E3 Ubiquitin-protein Ligase RNF138, Nemo-like Kinase-associated RING Finger Protein, RING Finger Protein 138, MGC8758) (MaxLight 750)
Sign In for Pricing
View Details