CAN508
Product Specifications
CAS Number
140651-18-9
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
CAN508 is a potent ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It also competitively inhibits Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 μM and 20 μM, respectively. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. [Antitumor activity.]
Smiles
Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1
Molecular Formula
C9H10N6O
Molecular Weight
218.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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