Poziotinib hydrochloride
Product Specifications
CAS Number
1429757-68-5
Target
EGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Purity
0.9981
Bioactivity
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
Smiles
Cl.COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C
Molecular Formula
C23H22Cl3FN4O3
Molecular Weight
527.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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