KRAS inhibitor-9
Product Specifications
CAS Number
300809-71-6
Target
Kras, Ras, Apoptosis
Related Pathways
Apoptosis, GPCR/G Protein, MAPK
Purity
0.9994
Bioactivity
KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSC-LC cells with KRAS mutation but not normal lung cells
Smiles
Nc1ccc(Sc2nc3ccccc3s2)c(Cl)c1
Molecular Formula
C13H9ClN2S2
Molecular Weight
292.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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