Sotorasib
Product Specifications
CAS Number
2296729-00-3
Target
Kras, Ras
Related Pathways
MAPK, GPCR/G Protein
Purity
0.9995
Bioactivity
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.
Smiles
O=C1N=C(C=2C=C(F)C(=NC2N1C=3C(=NC=CC3C)C(C)C)C=4C(F)=CC=CC4O)N5CCN(C(=O)C=C)CC5C
Molecular Formula
C30H30F2N6O3
Molecular Weight
560.594
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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