Zingerone

Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3].

Product Specifications

CAS Number

[122-48-5]

Product Name Alternative

Vanillylacetone; Gingerone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Zingerone.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(O)C=CC(CCC(C)=O)=C1

Molecular Formula

C11H14O3

Molecular Weight

194.23

Precautions

H315, H319, H335

References & Citations

[1]Ahmad B, et al. A Review on Pharmacological Properties of Zingerone (4- (4-Hydroxy-3-methoxyphenyl) -2-butanone) . ScientificWorldJournal. 2015;2015:816364.|[2]Ahmad B, et al. Zingerone (4- (4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation. Saudi Pharm J. 2018 Dec;26 (8) :1137-1145.|[3]Choi JS, et al. Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest. Int J Mol Sci. 2018 Sep 19;19 (9) .