3-Deazaadenosine (hydrochloride)
Product Specifications
UNSPSC Description
3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.
Target Antigen
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/3-Deazaadenosine_hydrochloride.html
Purity
99.67
Solubility
DMSO : 41.67 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Smiles
O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=C3)N=C2.Cl
Molecular Weight
302.718
References & Citations
[1]Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17.|[2]Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8.|[3]Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200.bioRxiv. 2024 May 18.|Am J Physiol Cell Physiol. 2023 Dec 25.|Arch Toxicol. 2021 Jan;95(1):299-309.|BMC Biol. 2024 May 3;22(1):104.|Cancer Cell Int. 2023 Dec 18;23(1):330.|Cancer Res. 2021 Sep 15;81(18):4778-4793.|Cell Mol Biol Lett. 2024 Jul 3;29(1):97.|Cell Rep. 2021 Jan 5;34(1):108580.|Environ Pollut. 2023 May 9;121798.|Exp Cell Res. 2024 Aug 27:114226.|Genomics. 2022 Jul 4;110424.|Int J Biol Sci. 2023; 19(2):593-609.|J Cancer. 2023 Apr 17; 14(7): 1117-1131.|J Neurosci. 2023 Jan 17;JN-RM-1209-22.|Oncogene. 2024 Mar 5.|Research Square Print. 2022 May.|Transpl Immunol. 2024 Jul 10:102083.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W013332A/3-Deazaadenosine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W013332A/3-Deazaadenosine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
86583-19-9
Available Sizes
Curated Selection
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