3-Deazaadenosine (hydrochloride)

3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

Product Specifications

CAS Number

[86583-19-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV; S-adenosylhomocysteine hydrolase (SAHH)

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/3-Deazaadenosine_hydrochloride.html

Purity

99.67

Solubility

DMSO : 41.67 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=C3)N=C2.Cl

Molecular Formula

C11H15ClN4O4

Molecular Weight

302.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270 (17) :3507-17.|[2]Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274 (27) :18981-8.|[3]Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104 (10) :1192-200.