Apcin
Product Specifications
CAS Number
300815-04-7
Target
APC/C
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9674
Bioactivity
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C (Cdc20) ) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.
Smiles
Cc1ncc(n1CCC(=O)NC(Nc1ccccc1)C(Cl)(Cl)Cl)[N+]([O-])=O
Molecular Formula
C13H14Cl3N7O4
Molecular Weight
438.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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