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Apcin

Product Specifications

CAS Number

300815-04-7

Target

APC/C

Related Pathways

Cell Cycle/Checkpoint

Purity

0.9674

Bioactivity

Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C (Cdc20) ) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.

Smiles

Cc1ncc(n1CCC(=O)NC(Nc1ccccc1)C(Cl)(Cl)Cl)[N+]([O-])=O

Molecular Formula

C13H14Cl3N7O4

Molecular Weight

438.65

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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