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Danicopan

Product Specifications

CAS Number

1903768-17-1

Target

Complement System

Related Pathways

Immunology/Inflammation

Purity

0.9994

Bioactivity

Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

Smiles

CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc(C)nc1

Molecular Formula

C26H23BrFN7O3

Molecular Weight

580.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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