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GMB-475

Product Specifications

CAS Number

2490599-18-1

Target

STAT, JAK, Apoptosis, PROTACs, Bcr-Abl

Related Pathways

Chromatin/Epigenetic, Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, PROTAC, Cytoskeletal Signaling, JAK/STAT signaling, Stem Cells

Purity

>99.99%

Bioactivity

GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL) .resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein

Smiles

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(cc2)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)C(C)(C)C)cc1

Molecular Formula

C43H46F3N7O7S

Molecular Weight

861.93

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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