AS2863619
Product Specifications
CAS Number
2241300-51-4
Target
STAT, CDK
Related Pathways
JAK/STAT signaling, Stem Cells, Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
AS2863619 is an oral inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19. Inhibition of CDK8/19 can enhance the activation of STAT5, thereby activating the Foxp3 gene. It can convert antigen-specific effector/memory T cells into Foxp3+ regulatory T cells to study various immune diseases.
Smiles
Cl.Cl.Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N
Molecular Formula
C16H14Cl2N8O
Molecular Weight
405.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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