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Adagrasib

Product Specifications

CAS Number

2326521-71-3

Target

Kras, Ras

Related Pathways

MAPK, GPCR/G Protein

Purity

0.999

Bioactivity

Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Smiles

CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12

Molecular Formula

C32H35ClFN7O2

Molecular Weight

604.12

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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