Adagrasib
Product Specifications
CAS Number
2326521-71-3
Target
Kras|||Ras
Related Pathways
MAPK|||GPCR/G Protein
Purity
0.999
Bioactivity
Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.
Smiles
CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12
Molecular Formula
C32H35ClFN7O2
Molecular Weight
604.12
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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