Cathepsin C-IN-5
Product Specifications
UNSPSC Description
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity[1].
Target Antigen
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cathepsin-c-in-5.html
Solubility
DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC(NC1=CC=CC(NC2=C(C=NC(NC3=NC=C(C=C3)C4=CSC=C4)=N2)Cl)=C1)=O
Molecular Weight
436.92
References & Citations
[1]Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146584/Cathepsin-C-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146584/Cathepsin-C-IN-5-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2825567-97-1
Available Sizes
Curated Selection
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