TfR-T12 (TFA)
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].
Product Specifications
UNSPSC
12352209
Target
Transferrin Receptor
Type
Peptides
Related Pathways
Apoptosis
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tfr-t12-tfa.html
Purity
99.10
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@H](C(C)C)NC([C@H](CCC2)N2C([C@H](CO)NC([C@@H](NC([C@H](CCSC)NC([C@H](CCC3)N3C([C@H](CCC4)N4C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)CC8=CNC9=CC=CC=C89.OC(C(F)(F)F)=O
Molecular Formula
C73H100F3N19O17S
Molecular Weight
1604.75
References & Citations
[1]Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68) Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13 (2) :332-41.|[2]Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7 (1) :3487.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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